The proposed relationship of Maria Elizabeth Hoffheins as the mother of John Stonecypher and George Washington Stonecipher is supported by DNA evidence indicating shared ancestry within the family lines.

Specifically, DNA evidence confirms a distant cousin relationship between KY (a descendant of the George Washington Stonecipher ancestral line) and RDC (a descendant of the John Stonecypher ancestral line) with a shared segment of 14.08 cM across 1 HIR segments.

This match is consistent with their placement within these shared ancestral branches.